Skin Deep - Clinical & Cosmetic Dermatology Blog

Skin Deep is a blog for dermatologists and skin care professionals with focus on theoretical, cosmetic and aesthetic dermatology. This blog is associated with ‘Dermatologists Sans Borders’ one of the largest curated groups of skin care professionals on facebook. If you are looking for non-technical information, please visit http://skinhelpdesk.com


Study Calls Into Question Sunscreen in Melanoma Prevention

Sunscreen might not be protective against skin cancer, according to a study that used new moles as a marker of melanoma risk in children, but the newer broad-spectrum products could be more effective.
Medscape Medical News

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Functional annotation of putative conserved proteins from Borrelia burgdorferi to find potential drug targets

The spirochete Borrelia burgdorferi is causative agent of Lyme disease. We have used various bioinformatics tools for predicting the function of unknown proteins present in B. burgdorferi's genome. While analysing the proteome data of B. burgdorferi, we have found 819 proteins. Out of these, 241 proteins are conserved hypothetical proteins (HPs), i.e., proteins of unspecified structures and biochemical functions. We have successfully annotated 120 HPs, and their corresponding functions have been predicted using different tools. On the basis of predicted functions, we have divided them into functional classes. Annotation and identification of functionally important regions in HPs from B. burgdorferi will enhance our understanding of new functional proteins, virulence mechanism and adaptability in host system.

By Shama Khan; Mohammad Sarwar Jamal; Farah Anjum; Mahmood Rasool; Abulaish Ansari; Asimul Islam; Faizan Ahmad; Md. Imtaiyaz Hassan in International Journal of Computational Biology and Drug Design (IJCBDD), 2016 Vol. 9 No. 4, pp. 295 - 318

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Interventional treatments for Hailey–Hailey disease

Hailey–Hailey disease or familial benign chronic pemphigus is a rare blistering dermatosis that is characterized by recurrent erythematous plaques with a predilection for the skin folds. For extensive Hailey–Hailey disease that is recalcitrant to conventional therapy, laser ablation, photodynamic therapy, electron beam radiotherapy, botulinum toxin type A, dermabrasion, glycopyrrolate, and afamelanotide have been reported as useful treatments, but comparative trials are lacking. This review discusses the various treatment modalities for Hailey–Hailey disease and a summary of the evidence for the most recommended treatments.

By Benjamin Farahnik, Collin M. Blattner, Michael B. Mortazie, Benjamin M. Perry, William Lear, Dirk M. Elston

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Trends in tickborne diseases

Tickborne diseases are a significant health problem in the United States with over 40,000 confirmed or probable cases reported as recently as 2014. Almost 80% of these cases consist of Lyme disease, but other diseases, including viral infections, are present and have been increasing in number over the past 20 years. Experts in tickborne diseases share updates about what’s new and what’s changing in the detection and transmission of these diseases.

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Nearly 50% Reduction in Diabetic Foot Ulcers With Stem Cells

Injection of autologous mesenchymal stem cells into diabetic foot ulcers that did not respond to standard of care and offloading resulted in a 50% reduction in ulcer size at 6 weeks in a pilot study.
Medscape Medical News

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Who detects melanoma? Impact of detection patterns on characteristics and prognosis of patients with melanoma

Despite the importance of early diagnosis, patients with cutaneous melanoma often seek consultation at advanced stages of the disease. The impact on prognosis according to who first detects the primary tumor has not been established.

By José Antonio Avilés-Izquierdo, Irene Molina-López, Enrique Rodríguez-Lomba, Ivan Marquez-Rodas, Ricardo Suarez-Fernandez, Pablo Lazaro-Ochaita

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Randomized placebo control study of insulin sensitizers (Metformin and Pioglitazone) in psoriasis patients with metabolic syndrome (Topical Treatment Cohort)

Increased prevalence of metabolic syndrome (MS) is observed in psoriasis. Metformin has shown improvement in cardiovascular risk factors while pioglitazone demonstrated anti proliferative, anti-inflammatory an...

By Surjit Singh and Anil Bhansali

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About Me

As a Dermatologist and Informatician my research mainly involves application of bioinformatics techniques and tools in dermatological conditions. However my research interests are varied and I have publications in areas ranging from artificial intelligence, sequence analysis, systems biology, ontology development, microarray analysis, immunology, computational biology and clinical dermatology. I am also interested in eHealth, Health Informatics and Health Policy.

Address

Bell Raj Eapen
Hamilton, ON
Canada