Skin Deep - Clinical & Cosmetic Dermatology Blog

Skin Deep is a blog for dermatologists and skin care professionals with focus on theoretical, cosmetic and aesthetic dermatology. This blog is associated with ‘Dermatologists Sans Borders’ one of the largest curated groups of skin care professionals on facebook. If you are looking for non-technical information, please visit http://skinhelpdesk.com


Comparison of single-spot technique and RGB imaging for erythema index estimation

A commercially available point measurement device, the Mexameter ® , and an experimental RGB imaging prototype device were used for erythema index estimation of 50 rosacea patients by analysing the level of skin redness on the forehead, both cheeks and both sides of a nose. Results are compared with Clinician’s Erythema Assessment (CEA) values given by two dermatologists. The Mexameter uses 568 nm and 660 nm LEDs and a photodetector for estimation of erythema index, while the used prototype device acquired RGB images at 460 nm, 530 nm and 665 nm LED illumination. Several erythema index estimation algorithms were compared to determine which one gives the best contrast between increased erythema and normal skin. The erythema index estimations and CEA values correlated muc...

By Physiological Measurement

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Skin Barrier Function and Allergens.

Authors: Engebretsen KA, Thyssen JP Abstract The skin is an important barrier protecting us from mechanical insults, microorganisms, chemicals and allergens, but, importantly, also reducing water loss. A common hallmark for many dermatoses is a compromised skin barrier function, and one could suspect an elevated risk of contact sensitization (CS) and allergy following increased penetration of potential allergens. However, the relationship between common dermatoses such as psoriasis, atopic dermatitis (AD) and irritant contact dermatitis (ICD) and the development of contact allergy (CA) is complex, and depends on immunologic responses and skin barrier status. Psoriasis has traditionally been regarded a Th1-dominated disease, but the discovery of Th17 cells and IL-17 provides new and...

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By Current Problems in Dermatology

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Laser-assisted drug delivery in dermatology: from animal models to clinical practice

English: Drug Delivery through skin
English: Drug Delivery through skin (Photo credit: Wikipedia)
Topical medicaments are the mainstay of the dermatologists’ therapeutic arsenal. Laser-assisted drug delivery enhances the ability of topically applied medicaments to penetrate the skin. We discuss the mechanisms of laser-assisted drug delivery and animal models that have informed clinical practice. We review clinical studies that have employed laser-assisted drug delivery for a range of indications to date including non-melanoma skin cancer, vitiligo, scarring, vaccination, local anaesthesia, analgesia, viral warts, infantile haemangiomas and cosmetic uses. Studies thus far suggest that laser pre-treatment improves transepidermal absorption of topical agents and allows for a much deeper penetration of drugs than is possible with topical medicaments alone. This may allo...

By Lasers in Medical Science

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Does maggot therapy promote wound healing? The clinical and cellular evidence

http://www.nih.gov/nihrecord/07_20_2004/images...
http://www.nih.gov/nihrecord/07_20_2004/images/sated.jpg (Photo credit: Wikipedia)
The larvae of Lucillia sericata, or maggots of the green‐bottle fly, are used worldwide to help debride chronic, necrotic and infected wounds. Whilst there is abundant clinical and scientific evidence to support the role of maggots for debriding and disinfecting wounds, not so much emphasis has been placed on their role in stimulating wound healing. However, there is accumulating evidence to suggest that maggots and their externalized secretions may also promote wound healing in stubborn, recalcitrant chronic ulcers. There are a growing number of clinical reports which support the observation that wounds which have been exposed to a course of maggot debridement therapy also show earlier healing and closure end‐points. In addition, recent pre‐clinical laboratory studies also ...

By Journal of the European Academy of Dermatology and Venereology

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The microbiome and Dermatological Diseases

English: A complete diagram of the human skin.
English: A complete diagram of the human skin. (Photo credit: Wikipedia)
The human skin harbours hundreds of species of commensal organisms, collectively known as the skin microbiota. The composition of the microbiota can be modified by various factors, such as host genotype, diet, antibiotics, hygiene, and pathogen infections, among others. Changes in these factors can cause microbiome disruption known as dysbiosis, leading to the outgrowth of potential pathogenic bacteria or a decrease in the number of beneficial bacteria. Dysbiosis has been implicated in some dermatological diseases. This mini-review aims to discuss the topic of the skin microbiota and its potential effects on various skin diseases. (Source: Postepy higieny i medycyny doswiadczalnej)

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The use of botanical products and vitamins in sunscreens.

English: UVA protection logo on sunscreens (Eu...
English: UVA protection logo on sunscreens (European Union) (Photo credit: Wikipedia)
The use of botanical products and vitamins in skin care creams and sunscreens is prevalent. Herein we conduct an evaluation of sunscreens to quantitatively assess how often sunscreens incorporate botanically derived products and vitamins. The most commonly used botanicals products and vitamins are identified and stratified based on the sunscreen sun protection factor (SPF). The overall prevalence for the use of botanical agents and vitamins was 62% and 79%, respectively. Aloe vera and licorice root extracts were the most common botanical agents used in sunscreens. Retinyl palmitate was the most common vitamin derivative utilized in sunscreens. The prices of sunscreens significantly increased when more than one bot...


By Dermatol Online J

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A potential role for the dermatologist in the physical transformation of transgender people: A survey of attitudes and practices within the transgender community

There are an estimated 700,000 or more transgender people in the United States, however their dermatologic needs are not fully established in the medical literature. Unique needs relate to hormone therapy, prior surgeries, and other aspects of physical transitioning.

By Brian A. Ginsberg, Marcus Calderon, Nicole M. Seminara, Doris Day

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A Retrospective Study of Patient Satisfaction Following a Trial of Nano-fractional RF Treatment.

Authors: Ray M, Gold M Abstract Traditional techniques used to treat dermatological conditions have typically involved surgery or full ablation of tissue. With the emergence of fractional radiofrequency (RF) technology, treatment for various skin conditions no longer requires surgery or full ablation. Instead, these treatment techniques deliver thermal energy, derived from fractional RF energy, in a highly targeted manner through multiple micro-needles, referred to as pins. This technique hastens recovery time and leads to less reported side effects associated with traditional methods of tissue augmentation. While the efficacy of this treatment has been demonstrated, patient satisfaction has not been assessed and documented thoroughly. The current study examined patient-reported sa...

By Journal of Drugs in Dermatology

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Case series supports oral itraconazole for infantile hemangiomas

COPENHAGEN – Ever since Dr. Yuping Ran published his initial report of successful treatment of infantile hemangiomas using oral itraconazole, dermatologists from around the world have been bombarding him with the same three questions: Does it really work? Is the treatment safe? What’s the mechanism... (Source: Skin and Allergy News)

By Skin and Allergy News

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About Me

As a Dermatologist and Informatician my research mainly involves application of bioinformatics techniques and tools in dermatological conditions. However my research interests are varied and I have publications in areas ranging from artificial intelligence, sequence analysis, systems biology, ontology development, microarray analysis, immunology, computational biology and clinical dermatology. I am also interested in eHealth, Health Informatics and Health Policy.

Address

Bell Raj Eapen
Hamilton, ON
Canada