Skin Deep - Clinical & Cosmetic Dermatology Blog

Skin Deep is a blog for dermatologists and skin care professionals with focus on theoretical, cosmetic and aesthetic dermatology. This blog is associated with ‘Dermatologists Sans Borders’ one of the largest curated groups of skin care professionals on facebook. If you are looking for non-technical information, please visit http://skinhelpdesk.com


Who detects melanoma? Impact of detection patterns on characteristics and prognosis of patients with melanoma

Despite the importance of early diagnosis, patients with cutaneous melanoma often seek consultation at advanced stages of the disease. The impact on prognosis according to who first detects the primary tumor has not been established.

By José Antonio Avilés-Izquierdo, Irene Molina-López, Enrique Rodríguez-Lomba, Ivan Marquez-Rodas, Ricardo Suarez-Fernandez, Pablo Lazaro-Ochaita

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Randomized placebo control study of insulin sensitizers (Metformin and Pioglitazone) in psoriasis patients with metabolic syndrome (Topical Treatment Cohort)

Increased prevalence of metabolic syndrome (MS) is observed in psoriasis. Metformin has shown improvement in cardiovascular risk factors while pioglitazone demonstrated anti proliferative, anti-inflammatory an...

By Surjit Singh and Anil Bhansali

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Computer-aided classification of melanocytic lesions using dermoscopic images: Low reported accuracy for reader study on melanomas with low melanoma in situ to invasive melanoma ratio

To the Editor: The report by Ferris et al1 represents a milestone in comparison of human and computer performance in melanoma detection. The receiver operating characteristic (ROC) curve analysis portrays the sensitivity-specificity tradeoff inherent in any diagnostic system. The study includes nonmelanocytic lesions, representing the clinical situation better than most previous computer-aided diagnostic studies.

By Bryce Schumacher, Nabin K. Mishra, Stephen W. Dusza, Allan C. Halpern, William V. Stoecker

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Screening for psoriatic arthritis using the PEST questionnaire: examining the optimal cutoff

Abstract

With great interest we read the recently published article in this journal by Laura Coates et al(1). Indeed, early detection of psoriatic arthritis (PsA) in patients with psoriasis is necessary to adequately treat concomitant joint disease, which can significantly impact quality of life(2,3).

This article is protected by copyright. All rights reserved.



By E.F.A. Leijten, V. Sigurdsson, M.H. Wenink, T.R.D.J. Radstake

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Which Psoriasis Biologics Have the Best Response Rates?

Dr Graeme Lipper reviews a retrospective observational study that sought to find out how long patients stayed on a biologic drug they were taking to treat psoriasis.
Medscape Dermatology

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The infliximab biosimilar in the treatment of moderate to severe plaque psoriasis

The infliximab originator's patent recently expired, leading to the production of biosimilar versions of the drug. The biosimilars' efficacy was not tested on patients with psoriasis but most regulatory authorities approved their use in psoriasis because of an extrapolation of data from studies conducted in other diseases.

By Paolo Dapavo, Igor Vujic, Maria Teresa Fierro, Pietro Quaglino, Martina Sanlorenzo

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The Golden Ratio of Beauty—A Hidden Treasure

Represented by the Greek letter φ, the golden ratio is characterized as an irrational number, approximately equal to 1.61803. It is often expressed through the division of a line into 2 parts, so that the proportion of the entire line to its longer part is equivalent to the ratio of the longer part to the shorter part. The Fibonacci sequence is another tool that may be used to derive the golden ratio. As the sequence is taken out to infinity, each integer may be divided by the preceding integer, yielding the same proportion.

By Mlacker S, Shah VV, Aldahan AS, et al.

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About Me

As a Dermatologist and Informatician my research mainly involves application of bioinformatics techniques and tools in dermatological conditions. However my research interests are varied and I have publications in areas ranging from artificial intelligence, sequence analysis, systems biology, ontology development, microarray analysis, immunology, computational biology and clinical dermatology. I am also interested in eHealth, Health Informatics and Health Policy.

Address

Bell Raj Eapen
Hamilton, ON
Canada