Skin Deep - Clinical & Cosmetic Dermatology Blog

Skin Deep is a blog for dermatologists and skin care professionals with focus on theoretical, cosmetic and aesthetic dermatology. This blog is associated with ‘Dermatologists Sans Borders’ one of the largest curated groups of skin care professionals on facebook. If you are looking for non-technical information, please visit

Acute generalised exanthematous pustulosis (AGEP)

This patient presented to me with sudden onset of widespread non follicular pustules over his body. He did not give personal or family history of psoriasis. My diagnosis was Acute generalised exanthematous pustulosis (AGEP). AGEP is a condition characterised by sudden onset of non-follicular aseptic pustules all over the body. Among drug-induced skin eruptions, AGEP is remarkable by its short time to onset after the administration of the suspected drug (less than 24 hours) and the great predominance (80%) of antibiotics as causative agents. Though it is generally easy to elicit a drug history in AGEP, I did not succeed. After 2 days patient called me and told that he remembered taking an Ayurvedic concoction called arishtam on the previous day of erruption. A literature search showed that, after drug reactions, the most common causes of AGEP are acute infections with enteroviruses, and hypersensitivity to mercury. Without taking sides, let me refer you to this article here:
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About Me

As a Dermatologist and Informatician my research mainly involves application of bioinformatics techniques and tools in dermatological conditions. However my research interests are varied and I have publications in areas ranging from artificial intelligence, sequence analysis, systems biology, ontology development, microarray analysis, immunology, computational biology and clinical dermatology. I am also interested in eHealth, Health Informatics and Health Policy.


Bell Raj Eapen
Hamilton, ON