Anti-inflammatory effects of a topical preparation containing nicotinamide: "Anti-inflammatory effects of a topical preparation containing nicotinamide, retinol, and 7-dehydrocholesterol in patients with acne: a gene expression study"
'via Blog this'
This study published recently in dovepress journal, Clinical, Cosmetic and Investigational Dermatology highlights the importance of dysregulation of matrix metalloproteinase (MMP) and pro inflammatory cytokines like IL-6
in acne. The study shows that many MMPs
and IL-6 are down-regulated when a topical preparation containing nicotinamide, retinol, and 7-dehydrocholesterol is applied. But does it mean that these MMPs are up-regulated in active acne? Except for MMP1, all other MMPs found to be down-regulated are gelatinases
and not collagenases. Zinc is an important cofactor for MMPs while doxycycline is an inhibitor. Both are found to be useful in the treatment of acne. So the MMP expression changes demonstrated in this study could just be an incidental finding!
Labels: acne, Cosmetic, MMP