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Skin Deep is a blog for dermatologists and skin care professionals with focus on theoretical, cosmetic and aesthetic dermatology. This blog is associated with ‘Dermatologists Sans Borders’ one of the largest curated groups of skin care professionals on facebook. If you are looking for non-technical information, please visit

Gene expression study in Acne

Acne vulgaris ill artlibre jn
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Anti-inflammatory effects of a topical preparation containing nicotinamide: "Anti-inflammatory effects of a topical preparation containing nicotinamide, retinol, and 7-dehydrocholesterol in patients with acne: a gene expression study"

'via Blog this'

This study published recently in dovepress journal, Clinical, Cosmetic and Investigational Dermatology highlights the importance of dysregulation of matrix metalloproteinase (MMP) and pro inflammatory cytokines like IL-6 in acne. The study shows that many MMPs and IL-6 are down-regulated when a topical preparation containing nicotinamide, retinol, and 7-dehydrocholesterol is applied. But does it mean that these MMPs are up-regulated in active acne? Except for MMP1, all other MMPs found to be down-regulated are gelatinases and not collagenases. Zinc is an important cofactor for MMPs while doxycycline is an inhibitor. Both are found to be useful in the treatment of acne. So the MMP expression changes demonstrated in this study could just be an incidental finding!

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About Me

As a Dermatologist and Informatician my research mainly involves application of bioinformatics techniques and tools in dermatological conditions. However my research interests are varied and I have publications in areas ranging from artificial intelligence, sequence analysis, systems biology, ontology development, microarray analysis, immunology, computational biology and clinical dermatology. I am also interested in eHealth, Health Informatics and Health Policy.


Bell Raj Eapen
Hamilton, ON