Skin Deep - Clinical & Cosmetic Dermatology Blog

Skin Deep is a blog for dermatologists and skin care professionals with focus on theoretical, cosmetic and aesthetic dermatology. This blog is associated with ‘Dermatologists Sans Borders’ one of the largest curated groups of skin care professionals on facebook. If you are looking for non-technical information, please visit

Platelet-derived growth factor (PRP Part 2)

English: Ribbon image of human PDGF receptor b...
English: Ribbon image of human PDGF receptor beta in complex with PDGF-B. This image was created using Pymol, based on 3MJG in the Protein Data Bank. (Photo credit: Wikipedia)
Did you read Part 1?

OK, Let us start our discussion on PRP with the Platelet Derived Growth Factor (PDGF) that served as a prototype growth factor for over 25 years. It plays an important role in blood vessel formation (angiogenesis) and it serves as an important mitogen for fibroblast through signalling pathways modulating cell cycle. Both these effects may be beneficial in skin rejuvenation. Though its overexpression has been linked to various fibrotic disorders and malignancies, it may not be important as far as PRP is concerned. However fibrotic skin disorders like scleroderma should be an important contraindication for PRP.  Here is a summary of PDGF from SLISE.

Read all articles in this series on PRP.

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About Me

As a Dermatologist and Informatician my research mainly involves application of bioinformatics techniques and tools in dermatological conditions. However my research interests are varied and I have publications in areas ranging from artificial intelligence, sequence analysis, systems biology, ontology development, microarray analysis, immunology, computational biology and clinical dermatology. I am also interested in eHealth, Health Informatics and Health Policy.


Bell Raj Eapen
Hamilton, ON