Skin Deep - Clinical & Cosmetic Dermatology Blog

Skin Deep is a blog for dermatologists and skin care professionals with focus on theoretical, cosmetic and aesthetic dermatology. This blog is associated with ‘Dermatologists Sans Borders’ one of the largest curated groups of skin care professionals on facebook. If you are looking for non-technical information, please visit

The PeelScore for PRP (PRP Part 6)

I am finally concluding my discussion on PRP. So what is your verdict? Mine is below. But before you read the verdict, please read all the articles in this series here.

wound healing in Drosophila. Cropped
wound healing in Drosophila. Cropped (Photo credit: Wikipedia)
PRP is an old technology. Its new incarnation is not drastically different from its former self. There is clinical proof for its usefulness in wound healing. However whether it can improve your looks remains to be seen. Many of the growth factors apparently present in higher concentration have diametrically opposite effects. Besides few of them like VEGF and IGF are known to contribute to not-so-pleasant cutaneous effects.  I give only 2 peels for Platelet-rich plasma (PRP) in cosmetic dermatology. peel rating
My Rating: 2 peels
What is peel score?

What is your rating?

BTW you may be wondering what a PeelScore is. Please read two of these posts on my personal blog that are not really personal. The first one is on peel score and the second is on medical shave!

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The Dark Knight Rises (PRP Part 5)

War (Photo credit: beapen)

This is a critical exploration of the potential utility (or otherwise) of Platelet Rich Plasma (PRP) in cosmetic treatments. Please read the rest of the articles in this series here.

Vascular endothelial growth factor (VEGF) is a signal protein that stimulates vasculogenesis and angiogenesis by binding to the VEGF receptors. VEGF receptors belong to the tyrosine kinase group and are implicated in the pathogenesis of melasma. In fact increased vascularity is emerging as the major pathogenic factor in melasma. The 578 Copper Bromide laser is supposed to improve melasma by reducing the expression of VEGF (Shall review separately later).

In short VEGF in PRP could potentially promote pigmentation. Its angiogenic potential is definitely useful in wound healing, but its anti-ageing property is dubious.

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The virtue of moderation (PRP Part 4)

Acanthosis nigricans
Acanthosis nigricans (Photo credit: Wikipedia)
Read the rest of the articles in this series on PRP.
(Platelet-rich Plasma)

Insulin like growth factor 1 and 2 (IGF-1 and IGF-2) have potent anabolic effects through the activation of AKT signalling pathway. Both are stimulators of cell growth and proliferation and inhibitor of apoptosis. Though it sounds attractive as far as anti-ageing is concerned, we must be mindful of its role in Acanthosis Nigricans. Acanthosis nigricans (AN) is a condition characterized by thickening and hyperpigmentation of the skin, typically of the intertriginous surfaces and neck. AN is emerging as an important clinical marker of insulin resistance (IR), where the associated hyperinsulinemia is thought to activate IGF-1 and FGFR receptors, thereby inducing the proliferation of keratinocytes. Increased bioavailability of IGF-1 has been implicated in AN (1).

1. Bhandari S Acanthosis Nigricans in Insulin Resistance Results from High IGF-1 and Insulin Levels. (

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About Me

As a Dermatologist and Informatician my research mainly involves application of bioinformatics techniques and tools in dermatological conditions. However my research interests are varied and I have publications in areas ranging from artificial intelligence, sequence analysis, systems biology, ontology development, microarray analysis, immunology, computational biology and clinical dermatology. I am also interested in eHealth, Health Informatics and Health Policy.


Bell Raj Eapen
Hamilton, ON