Skin Deep - Clinical & Cosmetic Dermatology Blog

Skin Deep is a blog for dermatologists and skin care professionals with focus on theoretical, cosmetic and aesthetic dermatology. This blog is associated with ‘Dermatologists Sans Borders’ one of the largest curated groups of skin care professionals on facebook. If you are looking for non-technical information, please visit

The Dark Knight Rises (PRP Part 5)

War (Photo credit: beapen)

This is a critical exploration of the potential utility (or otherwise) of Platelet Rich Plasma (PRP) in cosmetic treatments. Please read the rest of the articles in this series here.

Vascular endothelial growth factor (VEGF) is a signal protein that stimulates vasculogenesis and angiogenesis by binding to the VEGF receptors. VEGF receptors belong to the tyrosine kinase group and are implicated in the pathogenesis of melasma. In fact increased vascularity is emerging as the major pathogenic factor in melasma. The 578 Copper Bromide laser is supposed to improve melasma by reducing the expression of VEGF (Shall review separately later).

In short VEGF in PRP could potentially promote pigmentation. Its angiogenic potential is definitely useful in wound healing, but its anti-ageing property is dubious.

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About Me

As a Dermatologist and Informatician my research mainly involves application of bioinformatics techniques and tools in dermatological conditions. However my research interests are varied and I have publications in areas ranging from artificial intelligence, sequence analysis, systems biology, ontology development, microarray analysis, immunology, computational biology and clinical dermatology. I am also interested in eHealth, Health Informatics and Health Policy.


Bell Raj Eapen
Hamilton, ON