Skin Deep - Clinical & Cosmetic Dermatology Blog

Skin Deep is a blog for dermatologists and skin care professionals with focus on theoretical, cosmetic and aesthetic dermatology. This blog is associated with ‘Dermatologists Sans Borders’ one of the largest curated groups of skin care professionals on facebook. If you are looking for non-technical information, please visit

The virtue of moderation (PRP Part 4)

Acanthosis nigricans
Acanthosis nigricans (Photo credit: Wikipedia)
Read the rest of the articles in this series on PRP.
(Platelet-rich Plasma)

Insulin like growth factor 1 and 2 (IGF-1 and IGF-2) have potent anabolic effects through the activation of AKT signalling pathway. Both are stimulators of cell growth and proliferation and inhibitor of apoptosis. Though it sounds attractive as far as anti-ageing is concerned, we must be mindful of its role in Acanthosis Nigricans. Acanthosis nigricans (AN) is a condition characterized by thickening and hyperpigmentation of the skin, typically of the intertriginous surfaces and neck. AN is emerging as an important clinical marker of insulin resistance (IR), where the associated hyperinsulinemia is thought to activate IGF-1 and FGFR receptors, thereby inducing the proliferation of keratinocytes. Increased bioavailability of IGF-1 has been implicated in AN (1).

1. Bhandari S Acanthosis Nigricans in Insulin Resistance Results from High IGF-1 and Insulin Levels. (

Labels: , , , ,

Post a Comment

All comments, questions and criticisms welcome. Relevant comments with hyperlinks will be accepted. Though this form is not CommentLuv enabled, interesting and useful comments will be acknowledged with DoFollow links in the body of the post. Irrelevant comments and spam will be deleted.

Links to this post:

Create a Link

<< Home

About Me

As a Dermatologist and Informatician my research mainly involves application of bioinformatics techniques and tools in dermatological conditions. However my research interests are varied and I have publications in areas ranging from artificial intelligence, sequence analysis, systems biology, ontology development, microarray analysis, immunology, computational biology and clinical dermatology. I am also interested in eHealth, Health Informatics and Health Policy.


Bell Raj Eapen
Hamilton, ON