|Acanthosis nigricans (Photo credit: Wikipedia)|
Insulin like growth factor 1 and 2 (IGF-1 and IGF-2) have potent anabolic effects through the activation of AKT signalling pathway. Both are stimulators of cell growth and proliferation and inhibitor of apoptosis. Though it sounds attractive as far as anti-ageing is concerned, we must be mindful of its role in Acanthosis Nigricans. Acanthosis nigricans (AN) is a condition characterized by thickening and hyperpigmentation of the skin, typically of the intertriginous surfaces and neck. AN is emerging as an important clinical marker of insulin resistance (IR), where the associated hyperinsulinemia is thought to activate IGF-1 and FGFR receptors, thereby inducing the proliferation of keratinocytes. Increased bioavailability of IGF-1 has been implicated in AN (1).
1. Bhandari S et.al. Acanthosis Nigricans in Insulin Resistance Results from High IGF-1 and Insulin Levels. (http://professional.diabetes.org/Abstracts_Display.aspx?TYP=1&CID=52439)