Here is a quick review of few interesting articles before I go into peptides again.
|Example of dark circles (Photo credit: Wikipedia)|
|English: Uriticaria (Photo credit: Wikipedia)|
(3) As I concluded after my series on PRP, Platelet rich plasma is a mixture of growth factors with diametrically opposite effects. This study shows that excessively high concentrations of platelets actually have an inhibitory effect on the wound healing processes and are, therefore, counterproductive.
|Metformin (Photo credit: Wikipedia)|
(4)Metformin reduces hepatic glucose output and has anti-platelet and anti-oxidant effects. It has many non-diabetic cutaneous indications as well. This article reviews its beneficial effect on hirsutism, acne, hidradenitis suppurativa, acanthosis nigricans, psoriasis and skin cancer.
(5) The dermal filler manufacturers control the consistency and longevity of their products by altering the chain length and cross linking. Hyaluronic acid stabilized by carboxyl - hydroxyl inner esterification may have the additional benefit of pro-proliferative activity of cutaneous fibroblasts and keratinocytes.
1. Youn, S. "Correction of Infraorbital Dark Circles Using Collagenase-Digested ..." 2013. http://www.ncbi.nlm.nih.gov/pubmed/23437990
2. "Asthma Drug Curbs Chronic Hives." 2013. 25 Mar. 2013 http://www.medpagetoday.com/MeetingCoverage/AAAAI/37508
3. Giusti, Ilaria et al. "The effects of platelet gel–released supernatant on human fibroblasts." Wound Repair and Regeneration (2013).
4. Badr, D, M Kurban, and O Abbas. "Metformin in dermatology: an overview." Journal of the European Academy of Dermatology and Venereology (2013).
5. Wohlrab, Johannes, David Wohlrab, and Reinhard HH Neubert. "Comparison of noncross‐linked and cross‐linked hyaluronic acid with regard to efficacy of the proliferative activity of cutaneous fibroblasts and keratinocytes in vitro." Journal of cosmetic dermatology 12.1 (2013): 36-40.