Skin Deep - Clinical & Cosmetic Dermatology Blog

Skin Deep is a blog for dermatologists and skin care professionals with focus on theoretical, cosmetic and aesthetic dermatology. This blog is associated with ‘Dermatologists Sans Borders’ one of the largest curated groups of skin care professionals on facebook. If you are looking for non-technical information, please visit

The peptide avengers - Part 4

Read the full series here.

Matrixyl 3000 was a double-headed serpent (a mixture of Palmitoyl Oligopeptide & Palmitoyl Tetrapeptide-7). He had a weapon that others did not have: an anti-inflammatory sword. When Matrixyl’s son Tetrapeptide 21 was born, there was a voice from the heavens. “He who is born by immaculate bioinformatics shall rule the world of peptides. He shall win the heart of the elusive hyaluronic acid”.  If you want to read the transcript of the voice from heaven it is here. Please don’t forget to read the story of his bioinformatics birth and his effect on hyaluronic acid on page 2.

Here is my take on Tetrapeptide 21’s bioinformatics birth:
Please be warned that it is going to be a shameless self promotion without actually giving away much information. My plan is to get noticed by the top 100 cosmetic manufacturers.

The war still rages within....

English: Gene expression pattern of the HAS1 gene.
English: Gene expression pattern of the HAS1 gene. (Photo credit: Wikipedia)
Epilogue: Tetrapeptide 21 could not marry Hyaluronic Acid. He marries her slave HAS1 instead. Matrixyl 3000 marries copper and has a complex son. Read the story below.

[  Has1 and Has2 genes are regulated independently and synthesized hyaluronan may have a different function in epidermis and dermis.]

The war divides the country into chronological and photo ageing. The retinoids, fractional lasers for skin rejuvenation and dermarollers still rule the rest of the world.

Will be back with the story of Argireline.

Disclaimer: Matrixyl and Argireline are registered trademarks. All information presented here is given in good faith but without warranty or guarantee of any kind whatsoever, whether implied or expressed. 
Read the full series here.

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About Me

As a Dermatologist and Informatician my research mainly involves application of bioinformatics techniques and tools in dermatological conditions. However my research interests are varied and I have publications in areas ranging from artificial intelligence, sequence analysis, systems biology, ontology development, microarray analysis, immunology, computational biology and clinical dermatology. I am also interested in eHealth, Health Informatics and Health Policy.


Bell Raj Eapen
Hamilton, ON