Skin Deep - Clinical & Cosmetic Dermatology Blog

Skin Deep is a blog for dermatologists and skin care professionals with focus on theoretical, cosmetic and aesthetic dermatology. This blog is associated with ‘Dermatologists Sans Borders’ one of the largest curated groups of skin care professionals on facebook. If you are looking for non-technical information, please visit http://skinhelpdesk.com


10 reasons why nanobodies are better antibodies

Which is the latest monoclonal antibody for psoriasis? ----mab? (Feel free to use any four letters to fill in the blanks. Don't worry if it sounds strange today, it may not tomorrow). This will be followed by a series of expensive trials to prove the superiority of @@@mab of today to that of yesterday.

Polygon Medical Animation - Monoclonal Antibod...
Polygon Medical Animation - Monoclonal Antibody Therapy (Photo credit: Polygon Medical Animation)
Finally, there is a new technology in the horizon. The new technology actually simplifies things rather than complicate it. Ablynx, the developer observed what camels do with their antibodies and expunged unwanted parts of our conventional antibody. What remained was the single monomeric variable antibody domain. To their surprise, they found that the remaining antibody fragment  was more specific, had better affinity, low inherent toxicity, was easy to manufacture (hence cheaper) and could be administered through routes other than injection! Sounds like fairy tale? But it is true. Let me introduce the new hero Nanobody![1]

Comparison of (brown: human, blue: non-human):...
Comparison of (brown: human, blue: non-human): top row: mouse, chimeric bottom row: humanized, chimeric/humanized, human The substems according to the are shown below each antibody. (Photo credit: Wikipedia)
Most of the nanobodies are still on the drawing board. Some nanobodies may be specific enough to target fibrils in advanced stages of amyloid formation making it useful in Parkinsons.[2] A anti-Malassezia nanobody stable enough to be used in shampoos for dandruff is already being studied.[3] Very soon we might see a TV commercial of Embrel shampoo!

BTW, I have recently added a www to non-www redirect to this website. Please inform me if you notice any problems especially those using DKB webservices.

Disclaimer: Nanobody and Embrel are registered trade marks.

References:

1. "Understanding Nanobodies | Ablynx." 2010. 9 Apr. 2013 URL: http://www.ablynx.com/en/research-development/nanobody-technology/understanding-nanobodies/

2. Vuchelen, Anneleen et al. "1H, 13C and 15N assignments of a camelid nanobody directed against human α-synuclein." Biomolecular NMR assignments 3.2 (2009): 231-233.

3. Dolk, Edward et al. "Isolation of llama antibody fragments for prevention of dandruff by phage display in shampoo." Applied and environmental microbiology 71.1 (2005): 442-450.


Labels: , ,



Post a Comment

All comments, questions and criticisms welcome. Relevant comments with hyperlinks will be accepted. Though this form is not CommentLuv enabled, interesting and useful comments will be acknowledged with DoFollow links in the body of the post. Irrelevant comments and spam will be deleted.

Links to this post:

Create a Link

<< Home

About Me

As a Dermatologist and Informatician my research mainly involves application of bioinformatics techniques and tools in dermatological conditions. However my research interests are varied and I have publications in areas ranging from artificial intelligence, sequence analysis, systems biology, ontology development, microarray analysis, immunology, computational biology and clinical dermatology. I am also interested in eHealth, Health Informatics and Health Policy.

Address

Bell Raj Eapen
Hamilton, ON
Canada