Skin Deep - Clinical & Cosmetic Dermatology Blog

Skin Deep is a blog for dermatologists and skin care professionals with focus on theoretical, cosmetic and aesthetic dermatology. This blog is associated with ‘Dermatologists Sans Borders’ one of the largest curated groups of skin care professionals on facebook. If you are looking for non-technical information, please visit http://skinhelpdesk.com


Allured to Lignin Peroxidase

In this article I have reviewed lignin peroxidase (LIP) as a skin tone enhancing cosmetic. This is not a paid review.

Various types of cosmetic concealer.
Various types of cosmetic concealer. (Photo credit: Wikipedia)
Is it fair enough to say that 1.3 billion people in Indian sub-continent and many more in the far east have found the panacea for FAIR beautiful skin. Though only few of them will be able to afford LIP and the company aptly follows my time machine rules, I must say that I find the theory behind  LIP (distributed under a popular trade mark name) enticing.

The theory sans all the hype is simple: An isoenzyme of LIP (H1 or modified H2 to be exact) can oxidize melanin in the presence of an electron acceptor in acidic pH. So it is not, 'yet another tyrosinase inhibitor' and theoretically aid removal of already formed melanin. European CRO that reported their "Asian" trials  on company inscribed reports was hardly convincing  with their hanging "significant" improvement in 8 days.

The preparation transiently brings the cutaneous pH to acidic levels for LIP to have its effect. Once the pH returns to normal, LIP disintegrates and vanishes ensuring high safety profile. Since hypopigmenting properties of LIP secreting fungi are long known, this melanin zapper could be a reasonably good addition to any pigmentation treatment (if it were cheaper). It must be noted though that the patent application was filed in 2003 and the idea of a fungal derived fairness agent is not exactly theirs.

I have added LIP to the 'elimination' arm of Pigment Map Project. Do you agree with this placement?

I give 3 peels to the concept (The highest I have ever given to a cosmetic, despite 'sold only to aesthetic physician or spa' marketing gimmick ). Do give your rating using the widget below.

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Lignin peroxidase as a fairness cream
Reviewed by Bell Eapen on .
In this article I have reviewed lignin peroxidase (LIP) as a skin tone enhancing cosmetic. This is not a paid review.
Since hypopigmenting properties of LIP secreting fungi are long known, this melanin zapper could be a reasonably good addition to any pigmentation treatment.
PeelScore rating: 3


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About Me

As a Dermatologist and Informatician my research mainly involves application of bioinformatics techniques and tools in dermatological conditions. However my research interests are varied and I have publications in areas ranging from artificial intelligence, sequence analysis, systems biology, ontology development, microarray analysis, immunology, computational biology and clinical dermatology. I am also interested in eHealth, Health Informatics and Health Policy.

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Bell Raj Eapen
Hamilton, ON
Canada