Hyaluronic acid as a volume enhancer is an important tool in any dermatologist’s armamentarium. This interesting in vitro study demonstrated that HA has the potential to normalize some of the characteristic features of keloid fibroblasts such as hyperproliferation activity, growth factor production, and extracellular matrix deposition depending on the specific genotype of the keloid fibroblast cell line. Administration of high molecular weight HA is able to reverse keloid deficiencies such as hyperproliferation and aberrant ECM deposition to a more normal phenotype. Though it is still early days as the lab results do not always translate to clinical improvement, we may soon be injecting hyalunoric acid fillers into keloids instead of steroids.
Reference to full article below
Hoffmann A, Hoing JL, Newman M, Simman R. Role of Hyaluronic Acid Treatment in the Prevention of Keloid Scarring. The Journal of the American College of Clinical Wound Specialists 2012;4(2):23-31.
Labels: Extracellular matrix, keloid, scar