Skin Pathergy Test (SPT) – hypersensitivity of the skin to minimal trauma – is used as a diagnostic test in Behçet’s Disease with doubtful specificity. It is usually performed over the forearm with a blunt, sterilized needle. This article 2 recommends dermatoscopy for identifying sub-clinical pathergy reaction. The clinical relevance would have been much bigger if dermoscopy could replace biopsy in identifying pathergy. The authors have not clearly established the utility of dermoscopy in SPT. Authors have also mentioned about the significance of Thrombomodulin (TM) in pathergy. Thrombomodulin (TM) is a membrane-bound receptor of thrombin on vascular endothelial cells, which activates protein C and inactivates thrombin. High blood levels of TM were strongly correlated with positive skin pathergy test (SPT), suggesting that this test could be an alternative to the SPT.
Dermoscopy, reflectance confocal microscopy and immunohistochemical analysis in melanocytic lesions with meyerso... http://t.co/j88QZuciIe
— نادي الأمراض الجلدية (@DermClub) December 12, 2014
- Thatte Sarvesh S, Khopkar Uday S. The utility of dermoscopy in the diagnosis of evolving lesions of vitiligo. Indian journal of dermatology, venereology and leprology 2014;80(6):505-508. ↩
- Scherrer Maria A, Castro Lúcia P, Rocha Vanessa B, Pacheco Leonardo. The dermatoscopy in the skin pathergy testing: case series in patients with suspected behçet’s disease. Revista brasileira de reumatologia (english edition) 2014;54(6):494-498. ↩