Skin Deep - Clinical & Cosmetic Dermatology Blog

Skin Deep is a blog for dermatologists and skin care professionals with focus on theoretical, cosmetic and aesthetic dermatology. This blog is associated with ‘Dermatologists Sans Borders’ one of the largest curated groups of skin care professionals on facebook. If you are looking for non-technical information, please visit http://skinhelpdesk.com


Computer-assisted melanoma diagnosis: a new integrated system

Title: Pathology: Patient: Melanoma Descriptio...
Title: Pathology: Patient: Melanoma Description: This slide shows a melanoma on a patient's skin. Subjects (names): Topics/Categories: Pathology -- Patient Type: Black & White Print. Color Slide Source: National Cancer Institute Author: Unknown photographer/artist AV Number: AV-8500-3850 Date Created: 1985 Date Entered: 1/1/2001 Access: Public (Photo credit: Wikipedia)
In dermatology, attempts at synergy between man and machine have mainly been made to improve melanoma diagnosis. The aim of the present study was to test an ‘integrated digital dermoscopy analysis’ (i-DDA) system with a series of melanocytic lesions that were benign and malignant in nature, and to evaluate its discriminating power with respect to histological diagnosis. In a retrospective study we used an i-DDA system to evaluate a series of 856 excised, clinically atypical pigmented skin lesions (584 benign and 272 malignant). The system evaluated 48 parameters to be studied as possible discriminant variables, grouped into four categories (geometries, colours, textures and islands of colour) integrated with three personal metadata items (sex, age and site of lesion) and presence/absen...

By Melanoma Research

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Med Spa Patients and Laser Hair Removal / Botox Treatments

Laser-symbol
Laser-symbol (Photo credit: Wikipedia)
You’ve probably seen the ads for laser hair removal, inexpensive Botox and chemical peels. More and more, these services are being done at medical spas instead of doctor’s offices. There are hundreds of med spas and some people are sounding an alarm, saying as the industry grows, so do the numbers of injuries and lawsuits. Johanna Searles of Agawam still has scars from laser hair removal gone bad. “I kept saying ‘please, please stop. It’s burning,’” Searles told the I-Team of her visit to a med spa.
Johanna won a voucher for the treatment. She said the facility looked so professional, she figured it must be safe. “It had a doctor’s name right on the door. She had told me it was under a doctor’s supervision. They all...

By WBZ-TV - Breaking News, Weather and Sports for Boston, Worcester and New Hampshire

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Immunological Biomarkers in Dermatomyositis

This article reviews briefly the recently discovered molecules that are candidate immunological biomarkers for diagnosing and monitoring disease activity in DM. (Source: Current Rheumatology Reports)

By Current Rheumatology Reports

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Cohesivity of Hyaluronic Acid Fillers: Development and Clinical Implications of a Novel Assay, Pilot Validation with a Five-Point Grading Scale, and Evaluation of Six U.S. Food and Drug Administration–Approved Fillers

Conclusions: An evidence-based approach requires clinical corroboration of in vitro data. This new, reproducible cohesivity assay may have value together with elasticity (G') and viscosity measurements to understand and leverage distinct tissue distribution patterns and clinical behaviors of different hyaluronic acid products. CLINICAL QUESTION/LEVEL OF EVIDENCE: Therapeutic, V. (Source: Plastic and Reconstructive Surgery)

By Plastic and Reconstructive Surgery

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Contact dermatitis to cobalt chloride with an unusual mechanism

Contact Dermatitis to Cobalt in Dental Prosthesis: A Case report

This case report may serve to remind doctors to be aware of potential allergic reactions to prostheses and to enable them to recognize a metal allergy if it appears. Prosthetists should also be reminded of potential allergic reactions.

Cobalt can be used as an accelerator in making a prosthetic socket. Several cases have been reported concerning allergies to components of the prosthetic socket. This is the first report of sensitization to cobalt which is used in making a prosthetic leg. (Source: Prosthetics and Orthotics International)

By Prosthetics and Orthotics International

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Synergistic Mixtures of Anticancer Antibodies

Although antibodies against EGFR and HER2 are used to treat cancer, only some patients respond and resistance often emerges. Jacobsen and colleagues present in this issue experimental evidence favoring replacement of the currently applied monoclonal antibodies with oligoclonal mixtures of six synergistic antibodies, simultaneously engaging EGFR, HER2, and also HER3. Clin Cancer Res; 21(18); 4030–2. ©2015 AACR.

See related article by Jacobsen et al., p. 4110



By Yarden, Y., Sela, M.

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Recent knowledge: Concepts of dermal absorption in relation to skin decontamination

Decontamination of persons during a fire briga...
Decontamination of persons during a fire brigade exercise employment (Germany) (Photo credit: Wikipedia)

Skin decontamination is an important step mitigating percutaneous absorption through the stratum corneum (SC), which is also a highly complex process. Thus, understanding diffusion mechanisms and measuring dermal absorption rates are critical to protect humans from toxic exposures. Here, highly varied literature is placed in a biological and clinical perspective in regards to decontamination. Literature from PubMed and Surge Laboratory library files were searched and reviewed for relevance. Recent data have shown multiple layers of SC structural heterogeneity, which results in unique substance partitioning characteristics across the membrane. As such, attempts to model and understand this behavior in alternative in vitro membranes prove difficult.

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Psoriasis and herpes are most stigmatized dermatologic conditions

Attitudes toward psoriasis and herpes are significantly more stigmatizing than are perceptions of other dermatologic conditions, reported Dr. Jessica M. Donigan and her associates from Massachusetts General Hospital in... (Source: Skin and Allergy News)
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Consider finer needle for some facial onabotulinumtoxinA patients

English: An animated demonstration of the non-...
English: An animated demonstration of the non-retractable safety on a hypodermic needle. (Photo credit: Wikipedia)

Some patients may benefit from using finer needles for facial onabotulinumtoxinA injections, although the procedure is well tolerated by most. Results of a small randomized, double-blinded split-face study of 30- vs. 32-gauge needles found that the patient experience was improved for some when the... (Source: Skin and Allergy News)
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Uberizing Cosmetic Dermatology

Image Credit: BEP @ pixabay.com

Some time back, I read a story about a passenger finding it difficult to get a ride on Uber. He later realized that Uber has a two-way rating system with the passenger able to rate the driver and the driver rating the passenger. If your rating as a passenger drops, you may find it difficult to get lifts — or you may even be booted off the service entirely.


Setting up a cosmetic dermatology practice is expensive these days. A few unfair reviews on popular sites such as mouthshut could ruin your practice. There is also the risk of doctor shopping, planted fake reviews and an occasional body dysmorphic disorder patient holding a grudge on everybody. There is a growing realization that threat of an unfavorable review entitles you to premium treatment at reduced rates. Read Dr. Sunaina’s post on some common problems faced by dermatologists.

With the rapid commercialization, it is time for Uberizing cosmetic dermatology. The best way to ensure good behavior from clinics and patients is to have a dual rating system like Uber! This will help clinics to identify potential problem clients, just as patients can find cost-effective treatments. Here is such a system, FREE for everyone to use at http://skinhelpdesk.in. Clinic Managers can add your services to SkinHelpDesk. Potential clients can compare services and take appointments. Both can rate each other after an appointment.

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About Me

As a Dermatologist and Informatician my research mainly involves application of bioinformatics techniques and tools in dermatological conditions. However my research interests are varied and I have publications in areas ranging from artificial intelligence, sequence analysis, systems biology, ontology development, microarray analysis, immunology, computational biology and clinical dermatology. I am also interested in eHealth, Health Informatics and Health Policy.

Address

Bell Raj Eapen
Hamilton, ON
Canada