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Skin Deep is a blog for dermatologists and skin care professionals with focus on theoretical, cosmetic and aesthetic dermatology. This blog is associated with ‘Dermatologists Sans Borders’ one of the largest curated groups of skin care professionals on facebook. If you are looking for non-technical information, please visit

Functional annotation of putative conserved proteins from Borrelia burgdorferi to find potential drug targets

The spirochete Borrelia burgdorferi is causative agent of Lyme disease. We have used various bioinformatics tools for predicting the function of unknown proteins present in B. burgdorferi's genome. While analysing the proteome data of B. burgdorferi, we have found 819 proteins. Out of these, 241 proteins are conserved hypothetical proteins (HPs), i.e., proteins of unspecified structures and biochemical functions. We have successfully annotated 120 HPs, and their corresponding functions have been predicted using different tools. On the basis of predicted functions, we have divided them into functional classes. Annotation and identification of functionally important regions in HPs from B. burgdorferi will enhance our understanding of new functional proteins, virulence mechanism and adaptability in host system.

By Shama Khan; Mohammad Sarwar Jamal; Farah Anjum; Mahmood Rasool; Abulaish Ansari; Asimul Islam; Faizan Ahmad; Md. Imtaiyaz Hassan in International Journal of Computational Biology and Drug Design (IJCBDD), 2016 Vol. 9 No. 4, pp. 295 - 318

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About Me

As a Dermatologist and Informatician my research mainly involves application of bioinformatics techniques and tools in dermatological conditions. However my research interests are varied and I have publications in areas ranging from artificial intelligence, sequence analysis, systems biology, ontology development, microarray analysis, immunology, computational biology and clinical dermatology. I am also interested in eHealth, Health Informatics and Health Policy.


Bell Raj Eapen
Hamilton, ON